Categories
Podcast

Michael Lustgarten PhD. Scientist with a plan to conquer aging; how rigorous biomarker tracking can help us live longer

Dr. Lustgarten is a scientist at Human Nutrition Research Center on Aging at Tufts University with a mission to conquer aging through rigorous tracking of biomarkers. His Youtube videos, in which Dr. Lustgarten crunches scientific data in formats easily digestible by everyone and also provides his own biomarkers, are super educational and have inspired me personally in many ways. In our interview, we discuss his Youtube videos, his book Microbial Burden, his cutting-edge research on microbiome’s impacts on aging and much more! 

Video – Watch the interview on video

Audio – Listen to the interview

https://kenkohacks.com/wp-content/uploads/2021/07/Michael.mp3
Audio file

Timestamps

1:30 Dr. Lustgarten’s approaches to longevity; quantification through biomarkers
7:00 Dr. Lustgarten’s Youtube videos; health optimization and longevity
10:30 Reference values vs. optimal values; why you should focus on the latter
17:00 Dr. Lustgarten’s longevity strategies including dietary and exercise based approaches
20:00 Exercises’ impacts on maximum and average lifespans
21:40 Nutrition-dense food
33:40 How to optimize mineral intakes? “Small scales vs. big scales”
37:50 What’s adequate Vitamin K intake? RDA is not always optimal
38:55 Organ meats, carnivore diet
43:00 How to optimize mitochondrial health; exercise, fasting
48:00 Body’s water content (hydration); impacts of vegetables, muscle mass
51:07 Dr. Lustgarten’s book: Microbial Burden
57:56 Microbial metabolites
67:50 Exercises’ impacts on gut microbiome

Probiotics, prebiotics and bacterial metabolites
Optimal values and reference values for biomarkers

  
I cannot recommend highly enough Dr. Lustgarten’s videos on Youtube! They provide bite-sized takeaways for everyone that are based on solid sciences/measurements, whether you are a novice just getting started with biohacking or a seasoned biohacker. 

Dr. Lustgarten’s Youtube channel:  youtube.com/channel/UCT1UMLpZ_CrQ_8I431K0b-g (or search for Michael Lustgarten) 
Facebook: @mike.lustgarten 
Twitter: @mike_lustgarten 
Instagram: @conqueraging122
Microbial Burden on Amazon: amzn.to/2V5WhXR

Categories
Podcast

Interview with Martin Kremmer, co-founder of Danish Biohacker Community

In this interview Martin shares his experiences with biohacking, i.e. “becoming CEO of your own health“. He also discusses the Danish Biohacker Community, a Meet-up and Facebook group who has grown to more than 2000 members since its start in 2016.

https://kenkohacks.com/wp-content/uploads/2021/01/martin-kremmer.mp3
Interview with Martin Kremmer
Categories
Article

Peptide review: Humanin – mitochondrial peptide for weight loss, improved blood glucose, and reduced inflammation

Humanin, a 24 amino acids peptide, was almost simultaneously discovered independently by three scientific teams between 2001 and 2003. One of these teams was a Japanese lab led by Prof. Ikuo Nishimoto who was looking for a molecule that can potentially prevent or delay onset of Alzheimer’s disease. Their 2001 study shows humanin’s neuroprotective effect rescuing healthy neuro cells from death. Other researchers have reported humanin as an agent that improves insulin sensitivity and as an agent that increases cellular ATP levels.

Other noteworthy facts about humanin – I learnt them from this very educational SENSE talk by Pinchas Cohen

· It’s a naturally occurring peptide. Humanin is produced in and targets the mitochondria

· Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1) down-regulate humanin, and a higher level of GH & IGF-1 negatively correlates with that of humanin

· Humanin level is higher among centenarians

· It’s a caloric restriction mimetic, as opposed to Mots-c that is exercise mimetic

My N=1 experiment with the humanin peptide

It wasn’t easy to choose between humanin, Mots-C and SS 31 – all sounded equally attractive! After weeks of research, I finally decided on humanin because:

· I’m inclined to think a good idea to supplement with an endogenous peptide that declines with age. Humanin level sharply decreases with age, both in humans and mic

· I had just finished a round of Ipamorelin/CJC-1295. Given the inverse correlation, supplementing with humanin felt like a good idea

· My energy level was fine, and it felt more appealing for me to address cellular toxin protection with humanin

Dosage & timing: 1 mg twice a day. Humanin’s half-life in the body is about 30 minutes. Given the short half-life, the twice-a-daily protocol seemed better

To my knowledge there is no well-established human dose for humanin. Many animal studies administered higher dosages than human equivalent of 2 mg/d at my body weight of 58 kg. The daily 2 mg dosage was a balance between the safety, assumed effectiveness, and budget

Duration: Consecutive 15 days

Results: Despite its ATP increasing effect, humanin did not give me any jittery feeling. On the contrary, I felt a sense of calmness and wellbeing after humanin injections. This can of course be just placebo. I did not see any differences in my Oura scores or Lief Therapeutics’ daytime HRV scores

Verdict: I really liked the feeling of calmness I felt after the humanin injections. I plan a new treatment course and tweak the doses. During the 15 days I wasn’t wearing my Dexcom G6 and missed quantifying humanin’s blood glucose benefit…next time, I’ll make sure to have it on!

Please note that I’m sharing my personal experience for information sharing purpose only. I’m not making any recommendation or general statement about humanin and/or its applications