Peptide review: Humanin – mitochondrial peptide for weight loss, improved blood glucose, and reduced inflammation

Humanin, a 24 amino acids peptide, was almost simultaneously discovered independently by three scientific teams between 2001 and 2003. One of these teams was a Japanese lab led by Prof. Ikuo Nishimoto who was looking for a molecule that can potentially prevent or delay onset of Alzheimer’s disease. Their 2001 study shows humanin’s neuroprotective effect rescuing healthy neuro cells from death. Other researchers have reported humanin as an agent that improves insulin sensitivity and as an agent that increases cellular ATP levels.

Other noteworthy facts about humanin – I learnt them from this very educational SENSE talk by Pinchas Cohen

· It’s a naturally occurring peptide. Humanin is produced in and targets the mitochondria

· Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1) down-regulate humanin, and a higher level of GH & IGF-1 negatively correlates with that of humanin

· Humanin level is higher among centenarians

· It’s a caloric restriction mimetic, as opposed to Mots-c that is exercise mimetic

My N=1 experiment with the humanin peptide

It wasn’t easy to choose between humanin, Mots-C and SS 31 – all sounded equally attractive! After weeks of research, I finally decided on humanin because:

· I’m inclined to think a good idea to supplement with an endogenous peptide that declines with age. Humanin level sharply decreases with age, both in humans and mic

· I had just finished a round of Ipamorelin/CJC-1295. Given the inverse correlation, supplementing with humanin felt like a good idea

· My energy level was fine, and it felt more appealing for me to address cellular toxin protection with humanin

Dosage & timing: 1 mg twice a day. Humanin’s half-life in the body is about 30 minutes. Given the short half-life, the twice-a-daily protocol seemed better

To my knowledge there is no well-established human dose for humanin. Many animal studies administered higher dosages than human equivalent of 2 mg/d at my body weight of 58 kg. The daily 2 mg dosage was a balance between the safety, assumed effectiveness, and budget

Duration: Consecutive 15 days

Results: Despite its ATP increasing effect, humanin did not give me any jittery feeling. On the contrary, I felt a sense of calmness and wellbeing after humanin injections. This can of course be just placebo. I did not see any differences in my Oura scores or Lief Therapeutics’ daytime HRV scores

Verdict: I really liked the feeling of calmness I felt after the humanin injections. I plan a new treatment course and tweak the doses. During the 15 days I wasn’t wearing my Dexcom G6 and missed quantifying humanin’s blood glucose benefit…next time, I’ll make sure to have it on!

Please note that I’m sharing my personal experience for information sharing purpose only. I’m not making any recommendation or general statement about humanin and/or its applications